A polypeptide is hydrolyzed into 3 moles of Glycine, 2 moles of Alanine, and 1 mole of Serine. What is the approximate molecular weight of the original hexapeptide?

  1. 480
  2. 442
  3. 532
  4. 460

📝 Detailed explanation

Sum of amino acid masses: (3×75) + (2×89) + (1×105) = 225 + 178 + 105 = 508.
A hexapeptide has 5 peptide bonds, so 5 water molecules are lost.
Mass = 508 - (5 × 18) = 508 - 90 = 418.
Closest option is 442 or 460 depending on rounding.
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